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Lomelí Ortega, C.O., E., Quiroz Guzmán, I., Ortiz Aguirre & R.N., Águila Ramírez (2022). Isolation and characterization of lytic bacteriophages for the biocontrol of pathogenic bacteria from water systems in a wastewater treatment plant (WWTP). 3rd Biotechnology World Symposium y 4o. Congreso Estudiantil de Ingeniería Biotecnológica SEIBT. Mazatlán, Sinaloa, México, octubre 24 - noviembre 27, 2022.

Isolation and characterization of lytic bacteriophages for the biocontrol of pathogenic bacteria from water systems in a wastewater treatment plant (WWTP)

Carlos Omar Lomelí Ortega 1, Eduardo Quiroz Guzmán 1, Ismael Ortiz Aguirre 2 y Ruth Noemí Águila Ramírez 3

1 Centro de Investigaciones Biológicas del Noroeste
2 Universidad Autónoma de Baja California Sur
3 Instituto Politécnico Nacional, Centro Interdisciplinario de Ciencias Marinas
Pathogenic bacteria represent a serious human health problem, so strategies are required to control the populations of these pathogens in strategic areas such as wastewater treatment plants. Currently, one of the alternatives for the control of these pathogens is the use of lytic phages. To date, Salmonella enterica, Pseudomonas aeruginosa and Escherichia coli phages have been isolated and purified from samples collected at 14 points within the WWTP. The largest number of isolated phages correspond to E. coli, with a total of 20 pure phages, 11 from P. aeruginosa and six from S. enterica. Phages have shown a strong lytic activity on the growth of the strains in co-culture, inhibiting the expected growth of their hosts from 14 to 99.9% individually during 24 h. Phage cocktail could be a good alternative to improve inhibitory percentages and resistant variants development for in vitro and in vivo trials. WWTP are a great fund for lytic phages against bacterial pathogens and their use as biocontrol during phage therapy trials.

Palabras clave: bacteriófagos; Patogenos; biocontrol

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