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Resumen del producto

Tenorio-Rodriguez, P.A., H., Esquivel-Solis, J.I., Murillo-Álvarez, F., Ascencio, Á.I., Campa-Córdova & C., Angulo (2019). Biosprospecting potential of kelp (Laminariales, Phaeophyceae) from Baja California Peninsula: phenolic content, antioxidant properties, anti-inflammatory, and cell viability. Journal of Applied Phycology. 31: 3115-3129. DOI: 10.1007/s10811-019-01781-1.

Biosprospecting potential of kelp (Laminariales, Phaeophyceae) from Baja California Peninsula: phenolic content, antioxidant properties, anti-inflammatory, and cell viability

Paola A. Tenorio-Rodriguez, Hugo Esquivel-Solis, Jesús I. Murillo-Álvarez, Felipe Ascencio, Ángel I. Campa-Córdova y Carlos Angulo

To explore the potential of two kelps as natural sources of bioactive compounds, this study evaluated total phenolic content, antioxidantproperties,anti-inflammatory,andcellviabilityactivitiesofpolyphenol-enrichedfractionsfromEiseniaarboreaand Macrocystis pyrifera. Overall, the fractions from E. arborea had higher antioxidant properties than M. pyrifera. However, two fractions from E. arborea and M. pyrifera showed the strongest antioxidant activities among 12 fractions tested by polyphenol content, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), and Ferric reducing antioxidant power (FRAP) assays. Several fractions upregulated IL-10 gene expression and downregulated TNF-a and iNOS mRNA in RAW 264.7 cells. Remarkably, most of the fractions at the highest concentration (1280 µg mL -1) showed non-toxic effect on L9S29 cell line. Analysis of fractions by Fourier transformed infrared from attenuated total reflectance (FTIR-ATR) and by ultra-performance liquid chromatography coupledtoelectrosprayionizationquadrupoletimeofflightmassspectrometry(UPLC-ESI-Q-TOF-MS)suggestedthepresence of phlorotannins, such as phloroeckol, fucophloroethol, and phlorofucofuroeckol. In conclusion, the polyphenol content (phlorotannins)variedamongfractionsofmacroalgalspeciesandinfluencingtheirbiologicalproperties,whichrepresentnatural sources for health promotion.

Palabras clave: Eisenia arborea; Macrocystis pyrifera; Phlorotan

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