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Resumen del producto

Hernández Guerrero, C.J., E., Zubia, M.J., Ortega & J.L., Carballo (2007). Cytotoxic dibromostyrosine-derived metabolites from the sponge Aplysina gerardogreeni. Bioorganic & Medicinal Chemistry. 15(15): 5275-5282. DOI: 10.1016/j.bmc.2007.05.014.

Cytotoxic dibromostyrosine-derived metabolites from the sponge Aplysina gerardogreeni

Claudia Judith Hernández Guerrero, Eva Zubia, Maria J. Ortega y J. Luis Carballo

The chemical study of the sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by spectroscopic analysis and chemical methods. The new compounds and four semisynthetic analogues prepared in this study have shown cytotoxic activity against human tumor cell lines.

Palabras clave: sponges; Dibromotyrosine-derived metabolites; Natural products; Structure determination; Cytotoxicity

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