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Resumen del producto

Durán-Riveroll, L.M., B., Krock, A., Cembella, J., Peralta-Cruz, J.J., Bustillos-Guzmán & C.J., Band Schmidt (2017). Benzoyl analogs of the dinoflagellate Gymnodinium catenatum from the Gulf of California and the Pacific coast of Mexico as characterized by LC-MS/MS and NMR. P., L. A. O. and Hallegraeff, G. (Eds.), International Society for the Study of Harmful Algae 2017 (Ed.), Marine and Fresh-Water Harmful Algae. Proceedings of the 17th International Conference on Harmful Algae. pp.122-125.

Benzoyl analogs of the dinoflagellate Gymnodinium catenatum from the Gulf of California and the Pacific coast of Mexico as characterized by LC-MS/MS and NMR

Lorena M. Durán-Riveroll, Bernd Krock, Allan Cembella, Javier Peralta-Cruz, Jose J. Bustillos-Guzmán y Christine Johanna Band Schmidt

Gymnodinium catenatum is a chain-forming marine dinoflagellate, notorious for formation of harmful algalblooms (HABs) and production of paralytic shellfish toxins (PSTs), including a wide array of neurotoxicanalogs of saxitoxin (STX). Enhanced research efforts linked to improved detection and structuralelucidation techniques have led to discovery of a new group of STX derivatives, named GC toxins orbenzoyl analogs. We fractionated extracts of G. catenatum cultures by column chromatography and analyzedsemi-purified extracts by hydrophilic interaction liquid ion chromatography coupled with tandem massspectrometry (HILIC-MS/MS) and nuclear-magnetic resonance (NMR). We confirmed the presence of 15 ofthe 18 theoretical benzoyl toxins in isolates from the Pacific coast of Mexico. This is the first record of suchhigh relative and quantitative richness of the benzoyl toxins among cultured isolates. Benzoyl toxins are notroutinely monitored in shellfish and this might be a risk in seafood safety programs that rely exclusively onchemical analytical methods.

Palabras clave: Gymnodinium catenatum; benzoyl toxins; HILIC-tandem mass spectrometry; emerging toxins

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