Resumen del producto

The cytotoxic and ?-glucosidase inhibitory activity from organic extracts and fractions of sea urchin Eucidaris thouarsi and starfish Mithrodia bradleyi of Punta Arena de La Ventana, B. C. S., Mexico was evaluated. The cytotoxic activity of extracts and fractions (50 ?g mL^-1) toward different cancer cell lines U251, PC-3, K562, HCT-15, MCF-7 and SKLU were determined using the protein-binding dye sulforhodamine B assay in microculture to measure cell growth. Cell viability was determined by MTT assays against murine cell line J774. The inhibitory activity of ?-glucosidase (Type 1) of extracts and fractions assay was determined at different concentrations (1, 10 and 100 ?g mL^-1). The fraction F1 of M. bradleyi showed strong cytotoxicity but low cell viability against the cell line J774. While ether extract and fractions F2 and F4 of E. thouarsi showed a high and selective cytotoxicity against cancer cell lines. The fractions F3 and F4 of E. thouarsi, viscera extract and fraction F2 of M. bradleyi showed strong ?-glucosidase inhibitory activity similar to quercetin, which is a potent inhibitor used as reference. Eucidaris thouarsi and Mithrodia bradleyi displayed potential cytotoxic and ?-glucosidase inhibitory activity. Thus these organisms are a good source for the identification of active compounds.

Palabras clave: Marine invertebrate; cytotoxic activity; alpha-glucosidase inhibitory

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