Resumen del producto

Macroalgae have been recognized as a source of bioactive substances; currently have been associated with activity anticoagulant. This property has been the most studied due to the search for new therapeutic options to treat thrombotic and vascular conditions. The aim of the present work was to determine the relationship structure-activity of polysaccharides isolated from aqueous extracts from Codium simulans, C. amplivesciculatum, C. cuneatum and C. fragile. Afterward of ion exchange chromatography over DEAE-cellulose, fraction from C. simulans eluted with sodium chloride 0.5 M significantly increased the I.N.R. (19.9) at 320 ?g mL^-1. The mid-infrared spectral analysis of the active fraction from C. simulans showed the presence of absorption bands (3400, 2955, 1630, 1400, 1260, 1220, 1100, 1080, 1020, 950 and 820 cm^-1) characteristics for sulfated polysaccharides. In contrast, spectra from non-active fractions revealed the absence of absorption bands at 1260 and 820 cm^-1 due to vibration of
sulfate residues. In conclusion, in this study C. simulans appears to be the most promising source of polysaccharides with anticoagulant activity, which is strongly determined by the presence of sulfate ester residues. The remaining species studied showed just low activity.

Palabras clave: Seaweed extracts; seaweed; prothrombin time; Gulf of California

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