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Resumen del producto
Zaleta Pinet, D.A., I.P., Holland, M., Muñoz Ochoa, J.I., Murillo-Álvarez, J.A., Sakoff, I.A., van Altena & A., McCluskey
(2014).
Cytotoxic compounds from Laurencia pacifica.
Organic and Medicinal Chemistry Letters.
4(8): 1-7.
DOI: 10.1186/s13588-014-0008-8.
Cytotoxic compounds from Laurencia pacifica
Diana Angélica Zaleta Pinet, Ian P. Holland, Mauricio Muñoz Ochoa, Jesús Iván Murillo-Álvarez, Jennette A. Sakoff, Ian A. van Altena y Adam McCluskey
Background: The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica. Results: This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10?-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 ?M. Conclusions: Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development.
Palabras clave: Algae; Cytotoxicity; Laurencia pacifica; Sesquiterpenes; Anti-cancer
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