Resumen del producto

Seaweeds produce a great variety of secondary metabolites, especially Laurencia, a red algae that produce halogenated metabolites, terpenoides, acetogeninas and phenols, which have an important ecological role in the ocean. These compounds have shown several biological activities on pharmacological properties: cytotoxic, antibacterial, antifungal, antioxidant, anticoagulant, among others. The research of new drugs from seaweeds natural products has increased in the last decades. However, previous studies are needed to identify and characterize bioactive secondary metabolites. On this work we present the results of biological activity assays from crude ethanolic extracts and fractions of Laurencia johnstonii. Antibacterial activity was tested against three marine bacteria, Vibrio parahaemolyticus, Vibrio campbellii and Vibrio harveyi. We found better results on Vibrio harveyi, fraction 5 and 7 with a growth inhibition halo of 10.25 ± 0.17, 9.25 ± 0 respectively. Laurencia produces several bactericidal agents like amino acids, terpenoids, steroids, halogenated ketones, alkanes. For antioxidant activity we found positive results on apolar fractions (1-7). In general, it has been reported that antioxidant activity is directly proportional to the content of phenolic compounds such as flavonoids, tannins, quinones compounds are responsible for antioxidant, these are found in polar fractions, but our results show a synergic effect of several metabolites. Hemolytic activity was evaluated on crude extracts with a hemolysis halo of 8.5 mm ±.28, this activity is related to re presence of saponins, widely studied on Laurencia. Our results require more investigation, focused on the characterization, identification, isolation and purification of bioactive compounds on Laurencia johnstonii.

Palabras clave: Macroalgae; DPPH; rojas; Rhodophytae

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