Resumen del producto

Almost all studies in bioactivity of seaweed´s secondary metabolites have been focused on the antimicrobial activity, but recently some have been found with significant inhibitory effects against the growth of cancer cell lines. The organic extracts (ether and buthanol) of six marine seaweed (Laurencia johnstonii, Gymnogongrus martinensis, Ulva lactuca, Codium fragile, Dictyota flabellata and Padina concrescens) collected from the offshore waters of Gulf of California, México were in vitro screening for anticancer activity. First, all samples were tested at concentrations equivalent to 1 mg/ml to evaluate their inhibitory effect on the growth of cancer cell lines such as MCF-7 (drug-sensitive breast-tumor), HepG2 (human hepatocellular liver carcinoma), Caco2 (Human colonic carcinoma) and PC3 (Human prostate cancer) and compared to the observed on non-transformed cells such as NIH 3T3 (murine fibroblasts) to evaluate specificity against cancer cell lines. Only the ethereal extracts showed inhibitory activity to cancer cells growth. The samples that reduce the viability to less than 50% were tested again to evaluate the IC₅₀ (concentration of extract in media that reduce 50% of cell viability). The extracts of L. johnstonii, C. fragile and D. flabellata showed significative activity with IC₅₀ values lower than 0.06 mg/ml.

Palabras clave: Specialist; seaweeds; extractos; citotoxicos; bioactivity

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