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Resumen del producto
Zubia, E., M.J., Ortega, C.J., Hernández Guerrero & J.L., Carballo
(2008).
Isothiocyanate Sesquiterpenes from a Sponge of the Genus Axinyssa.
Journal of Natural Products.
71(4): 608-614.
DOI: 10.1021/np070593s.
Isothiocyanate Sesquiterpenes from a Sponge of the Genus Axinyssa
Eva Zubia, Maria J. Ortega, Claudia Judith Hernández Guerrero y J. Luis Carballo
The chemical study of a sponge of the genus Axinyssa collected in the Gulf of California has led to the isolation of the new bicyclic sesquiterpenes axinisothiocyanates A-L ( 1- 12) together with the known compounds (1 R,6 S,7 S,10 S)-10-isothiocyanato-4-amorphene ( 13), (4 R*,5 R*,7 S*,10 R*)-4-isocyanoeudesm-11-ene, (-)-epipolasin A, and (+)-aristolone. The structures of the new metabolites have been established by spectroscopic techniques, including the analysis of pyridine-induced 1H NMR chemical shifts. The cytotoxic activity has been tested against three human tumor cell lines.
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